Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies

HGF-Met signaling contributes to various biological events by controlling cell migration. Since the abnormal activation of Met receptor causes cancer progression, inhibitors such as neutralizing antibodies are regarded as promising therapeutics. HGF is secreted as a single-chain (sc) precursor and i...

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Udgivet i:Sci Rep
Main Authors: Umitsu, Masataka, Sakai, Katsuya, Ogasawara, Satoshi, Kaneko, Mika K., Asaki, Ryoko, Tamura-Kawakami, Keiko, Kato, Yukinari, Matsumoto, Kunio, Takagi, Junichi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017023/
https://ncbi.nlm.nih.gov/pubmed/27608665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33149
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