53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells

BACKGROUND: Mutations in DNA damage response factors BRCA1 and BRCA2 confer sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors in breast and ovarian cancers. BRCA1/BRCA2-defective tumors can exhibit resistance to PARP inhibitors via multiple mechanisms, one of which involves loss of 53BP1....

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Publicado en:BMC Cancer
Autores principales: Hong, Ruoxi, Ma, Fei, Zhang, Weimin, Yu, Xiying, Li, Qing, Luo, Yang, Zhu, Changjun, Jiang, Wei, Xu, Binghe
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017014/
https://ncbi.nlm.nih.gov/pubmed/27613518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2754-7
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