A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors

In many families of cell surface receptors, a single transmembrane (TM) α-helix separates ecto- and cytosolic domains. A defined coupling of ecto- and TM domains must be essential to allosteric receptor regulation but remains little understood. Here, we characterize the linker structure, dynamics, a...

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Publicat a:J Biol Chem
Autors principals: Schmidt, Thomas, Ye, Feng, Situ, Alan J., An, Woojin, Ginsberg, Mark H., Ulmer, Tobias S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016151/
https://ncbi.nlm.nih.gov/pubmed/27365391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.733683
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