Identification of a Conserved RNA-dependent RNA Polymerase (RdRp)-RNA Interface Required for Flaviviral Replication

Dengue virus, an ∼10.7-kb positive-sense RNA virus, is the most common arthropod-communicated pathogen in the world. Despite dengue's clear epidemiological importance, mechanisms for its replication remain elusive. Here, we probed the entire dengue genome for interactions with viral RNA-depende...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Hodge, Kenneth, Tunghirun, Chairat, Kamkaew, Maliwan, Limjindaporn, Thawornchai, Yenchitsomanus, Pa-thai, Chimnaronk, Sarin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016140/
https://ncbi.nlm.nih.gov/pubmed/27334920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.724013
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