Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo

Oncostatin M (OSM) is a multifunctional gp130 cytokine. Although OSM is produced in adipose tissue, it is not produced by adipocytes. OSM expression is significantly induced in adipose tissue from obese mice and humans. The OSM-specific receptor, OSM receptor β (OSMR), is expressed in adipocytes, bu...

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Vydáno v:J Biol Chem
Hlavní autoři: Elks, Carrie M., Zhao, Peng, Grant, Ryan W., Hang, Hardy, Bailey, Jennifer L., Burk, David H., McNulty, Margaret A., Mynatt, Randall L., Stephens, Jacqueline M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016111/
https://ncbi.nlm.nih.gov/pubmed/27325693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.739110
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