Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin

Pericentromeric heterochromatin (PCH) gives rise to highly dense chromatin sub-structures rich in the epigenetic mark corresponding to the trimethylated form of lysine 9 of histone H3 (H3K9me3) and in heterochromatin protein 1α (HP1α), which regulate genome expression and stability. We demonstrate t...

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Published in:Sci Rep
Main Authors: Mansuroglu, Zeyni, Benhelli-Mokrani, Houda, Marcato, Vasco, Sultan, Audrey, Violet, Marie, Chauderlier, Alban, Delattre, Lucie, Loyens, Anne, Talahari, Smail, Bégard, Séverine, Nesslany, Fabrice, Colin, Morvane, Souès, Sylvie, Lefebvre, Bruno, Buée, Luc, Galas, Marie-Christine, Bonnefoy, Eliette
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015075/
https://ncbi.nlm.nih.gov/pubmed/27605042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33047
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