Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge

PB10 is a murine monoclonal antibody against an immunodominant epitope on ricin toxin's enzymatic subunit. Here, we characterize a fully humanized version of PB10 IgG1 (hPB10) and demonstrate that it has potent in vitro and in vivo toxin-neutralizing activities. We also report the minimum serum...

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Publicado en:Clin Vaccine Immunol
Autores principales: Van Slyke, Greta, Sully, Erin K., Bohorova, Natasha, Bohorov, Ognian, Kim, Do, Pauly, Michael H., Whaley, Kevin J., Zeitlin, Larry, Mantis, Nicholas J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014922/
https://ncbi.nlm.nih.gov/pubmed/27466351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00088-16
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