An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to T(H)17-like cells

Mechanisms by which regulatory T (T(reg)) cells fail to control inflammation in asthma remain poorly understood. We show that a severe asthma-associated polymorphism in the interleukin-4 receptor alpha chain (IL4RA R576) promotes conversion of induced T(reg) (iT(reg)) cells towards a T helper 17 (T(...

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Bibliographic Details
Published in:Nat Med
Main Authors: Massoud, Amir Hossein, Charbonnier, Louis-Marie, Lopez, David, Pellegrini, Matteo, Phipatanakul, Wanda, Chatila, Talal A
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014738/
https://ncbi.nlm.nih.gov/pubmed/27479084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4147
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