Electroporation Enhanced Effect of Dystrophin Splice Switching PNA Oligomers in Normal and Dystrophic Muscle

Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting factor for development, and only few successful studies have been reported. As a possible modality for improvem...

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Bibliografische gegevens
Gepubliceerd in:Mol Ther Nucleic Acids
Hoofdauteurs: Brolin, Camilla, Shiraishi, Takehiko, Hojman, Pernille, Krag, Thomas O, Nielsen, Peter E, Gehl, Julie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014535/
https://ncbi.nlm.nih.gov/pubmed/26623939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.41
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