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Targeting TSLP With shRNA Alleviates Airway Inflammation and Decreases Epithelial CCL17 in a Murine Model of Asthma

Airway epithelium defends the invasion from microorganisms and regulates immune responses in allergic asthma. Thymic stromal lymphopoietin (TSLP) from inflamed epithelium promotes maturation of dendritic cells (DCs) to prime Th2 responses via CCL17, which induces chemotaxis of CD4(+) T cells to medi...

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Dades bibliogràfiques
Publicat a:Mol Ther Nucleic Acids
Autors principals: Chen, Yi-Lien, Chiang, Bor-Luen
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014514/
https://ncbi.nlm.nih.gov/pubmed/27138176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.29
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