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Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer

The heterodimeric laminin receptor α6β4 integrin plays a central role in the promotion of tumor cell growth, invasion, and organotropic metastasis. As an overproduction of the integrin is often linked to a poor prognosis, the inhibition of integrin α6β4 binding to laminin is of high therapeutical in...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Berg, Katharina, Lange, Tobias, Mittelberger, Florian, Schumacher, Udo, Hahn, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014452/
https://ncbi.nlm.nih.gov/pubmed/26978578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.10
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