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Binding of clinical inhibitors to a model precursor of a rationally selected multidrug resistant HIV-1 protease is significantly weaker than to the released mature enzyme

We have systematically validated the activity and inhibition of a HIV-1 protease (PR) variant bearing 17 mutations (PR(S17)), selected to represent high resistance by machine learning on genotype-phenotype data. Three of five mutations in PR(S17) correlating with major drug resistance, M46L, G48V an...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Biochemistry
मुख्य लेखकों: Park, Joon H., Sayer, Jane M., Aniana, Annie, Yu, Xiaxia, Weber, Irene T., Harrison, Robert W., Louis, John M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013724/
https://ncbi.nlm.nih.gov/pubmed/27039930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00012
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