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Binding of clinical inhibitors to a model precursor of a rationally selected multidrug resistant HIV-1 protease is significantly weaker than to the released mature enzyme
We have systematically validated the activity and inhibition of a HIV-1 protease (PR) variant bearing 17 mutations (PR(S17)), selected to represent high resistance by machine learning on genotype-phenotype data. Three of five mutations in PR(S17) correlating with major drug resistance, M46L, G48V an...
में बचाया:
में प्रकाशित: | Biochemistry |
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मुख्य लेखकों: | , , , , , , |
स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
2016
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5013724/ https://ncbi.nlm.nih.gov/pubmed/27039930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00012 |
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