Fragment-Based Whole Cell Screen Delivers Hits against M. tuberculosis and Non-tuberculous Mycobacteria

Reactive multi-target ‘fragment drugs’ represent critical components of current tuberculosis regimens. These compounds, such as pyrazinamide, are old synthetic antimycobacterials that are activated inside Mycobacterium tuberculosis bacilli and are smaller than the usual drug-like, single-target mole...

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Bibliografiska uppgifter
I publikationen:Front Microbiol
Huvudupphovsmän: Moreira, Wilfried, Lim, Jia Jie, Yeo, Si Ying, Ramanujulu, Pondy M., Dymock, Brian W., Dick, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2016
Ämnen:
Microbiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013068/
https://ncbi.nlm.nih.gov/pubmed/27656168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2016.01392
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