B4GALNT2 (GALGT2) Gene Therapy Reduces Skeletal Muscle Pathology in the FKRP P448L Mouse Model of Limb Girdle Muscular Dystrophy 2I

Overexpression of B4GALNT2 (previously GALGT2) inhibits the development of muscle pathology in mouse models of Duchenne muscular dystrophy, congenital muscular dystrophy 1A, and limb girdle muscular dystrophy 2D. In these models, muscle GALGT2 overexpression induces the glycosylation of α dystroglyc...

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Bibliographic Details
Published in:Am J Pathol
Main Authors: Thomas, Paul J., Xu, Rui, Martin, Paul T.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2016
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012513/
https://ncbi.nlm.nih.gov/pubmed/27561302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.05.021
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