Cerebellar Ataxia and Coenzyme Q Deficiency Through Loss of Unorthodox Kinase Activity

The UbiB protein kinase-like (PKL) family is widespread—comprising one-quarter of microbial PKLs and five human homologs—yet its biochemical activities remain obscure. COQ8A (ADCK3) is a mammalian UbiB protein associated with ubiquinone (CoQ) biosynthesis and an ataxia (ARCA2) through unclear means....

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Veröffentlicht in:Mol Cell
Hauptverfasser: Stefely, Jonathan A., Licitra, Floriana, Laredj, Leila, Reidenbach, Andrew G., Kemmerer, Zachary A., Grangeray, Anais, Jaeg-Ehret, Tiphaine, Minogue, Catherine E., Ulbrich, Arne, Hutchins, Paul D., Wilkerson, Emily M., Ruan, Zheng, Aydin, Deniz, Hebert, Alexander S., Guo, Xiao, Freiberger, Elyse C., Reutenauer, Laurence, Jochem, Adam, Chergova, Maya, Johnson, Isabel E., Lohman, Danielle C., Rush, Matthew J. P., Kwiecien, Nicholas W., Singh, Pankaj K., Schlagowski, Anna I., Floyd, Brendan J., Forsman, Ulrika, Sindelar, Pavel J., Westphall, Michael S., Pierrel, Fabien, Zoll, Joffrey, Dal Peraro, Matteo, Kannan, Natarajan, Bingman, Craig A., Coon, Joshua J., Isope, Philippe, Puccio, Hélène, Pagliarini, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012427/
https://ncbi.nlm.nih.gov/pubmed/27499294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.06.030
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