Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

BACKGROUND: The US Army designed artelinate/lysine salt (AL) to overcome the instability of sodium artesunate in aqueous solution (AS). To select the most efficacious artemisinin treatment, direct comparison was performed in an uncomplicated non-human primate malaria model. METHODS: Splenectomized r...

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Publicat a:Malar J
Autors principals: Teja-Isavadharm, Paktiya, Siriyanonda, Duangsuda, Rasameesoraj, Maneerat, Limsalakpeth, Amporn, Chanarat, Nitima, Komcharoen, Natthasorn, Weina, Peter J., Saunders, David L., Gettayacamin, Montip, Scott Miller, R.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5011932/
https://ncbi.nlm.nih.gov/pubmed/27599723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-016-1456-6
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