Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway

BACKGROUND: We previously demonstrated that neuregulin-1 (NRG-1) was neuroprotective in rats following ischemic stroke. Neuroprotection by NRG-1 was associated with the suppression of pro-inflammatory gene expression in brain tissues. Over-activation of brain microglia can induce pro-inflammatory ge...

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Publicado en:J Neuroinflammation
Main Authors: Simmons, Lauren J., Surles-Zeigler, Monique C., Li, Yonggang, Ford, Gregory D., Newman, Gale D., Ford, Byron D.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5011915/
https://ncbi.nlm.nih.gov/pubmed/27596278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0703-7
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