CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.

Míreanna Comhchosúla

• The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56lck tyrosine in human T-cells.
  le: Biffen, M, et al.
  Foilsithe: (1994)
• The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck.
  le: Raab, M, et al.
  Foilsithe: (1994)
• p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.
  le: Raab, M, et al.
  Foilsithe: (1995)
• Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.
  le: Shenoy-Scaria, A M, et al.
  Foilsithe: (1993)
• T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)
  Foilsithe: (1993)