OPTOGENETIC STIMULATION OF CORTICO-SUBTHALAMIC PROJECTIONS IS SUFFICIENT TO AMELIORATE BRADYKINESIA IN 6-OHDA LESIONED MICE

Electrical deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective for ameliorating the motor symptoms of Parkinson’s disease (PD) including bradykinesia. The STN receives its main excitatory input from cortex; however, the contribution of cortico-subthalamic projection neurons to...

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Udgivet i:Neurobiol Dis
Main Authors: Sanders, Teresa H., Jaeger, Dieter
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010926/
https://ncbi.nlm.nih.gov/pubmed/27452483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.07.021
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