Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men

CONTEXT: A subpopulation of hypothalamic neurons colocalize three neuropeptides, namely kisspeptin, neurokinin B (NKB), and dynorphin, collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis); kisspeptin stimulates, NKB modulates, and...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Narayanaswamy, Shakunthala, Prague, Julia K., Jayasena, Channa N., Papadopoulou, Deborah A., Mizamtsidi, Maria, Shah, Amar J., Bassett, Paul, Comninos, Alexander N., Abbara, Ali, Bloom, Stephen R., Veldhuis, Johannes D., Dhillo, Waljit S.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010567/
https://ncbi.nlm.nih.gov/pubmed/27379743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2016-1911
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