Evaluation of OASIS QSAR Models Using ToxCast™ in Vitro Estrogen and Androgen Receptor Binding Data and Application in an Integrated Endocrine Screening Approach

BACKGROUND: Integrative testing strategies (ITSs) for potential endocrine activity can use tiered in silico and in vitro models. Each component of an ITS should be thoroughly assessed. OBJECTIVES: We used the data from three in vitro ToxCast™ binding assays to assess OASIS, a quantitative structure-...

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Foilsithe in:Environ Health Perspect
Main Authors: Bhhatarai, Barun, Wilson, Daniel M., Price, Paul S., Marty, Sue, Parks, Amanda K., Carney, Edward
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Institute of Environmental Health Sciences 2016
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010395/
https://ncbi.nlm.nih.gov/pubmed/27152837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP184
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