Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions

The emergence and prevalence of drug resistance demands streamlined strategies to identify drug resistant variants in a fast, systematic and cost-effective way. Methods commonly used to understand and predict drug resistance rely on limited clinical studies from patients who are refractory to drugs...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Wong, Lai H., Sinha, Sunita, Bergeron, Julien R., Mellor, Joseph C., Giaever, Guri, Flaherty, Patrick, Nislow, Corey
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010250/
https://ncbi.nlm.nih.gov/pubmed/27588687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006275
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