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Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards

A computational framework was developed to assist in screening and prioritizing chemicals based on their dosimetry, toxicity, and potential exposures. The overall strategy started with contextualizing chemical activity observed in high-throughput toxicity screening (HTS) by mapping these assays to b...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: El-Masri, Hisham, Kleinstreuer, Nicole, Hines, Ronald N., Adams, Linda, Tal, Tamara, Isaacs, Kristin, Wetmore, Barbara A., Tan, Yu-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009469/
https://ncbi.nlm.nih.gov/pubmed/27208077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw082
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