EspR-dependent ESAT-6 Protein Secretion of Mycobacterium tuberculosis Requires the Presence of Virulence Regulator PhoP

Attenuation of Mycobacterium bovis BCG strain is related to the loss of the RD1-encoded ESX-1 secretion system. The ESX-1 system secretes virulence factor ESAT-6 that plays a critical role in modulation of the host immune system, which is essential for establishment of a productive infection. Previo...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Anil Kumar, Vijjamarri, Goyal, Rajni, Bansal, Roohi, Singh, Nisha, Sevalkar, Ritesh Rajesh, Kumar, Ashwani, Sarkar, Dibyendu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009273/
https://ncbi.nlm.nih.gov/pubmed/27445330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.746289
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