Selective Inhibition of Human Equilibrative and Concentrative Nucleoside Transporters by BCR-ABL Kinase Inhibitors: IDENTIFICATION OF KEY hENT1 AMINO ACID RESIDUES FOR INTERACTION WITH BCR-ABL KINASE INHIBITORS

Human nucleoside transporters (hNTs) mediate cellular influx of anticancer nucleoside drugs, including cytarabine, cladribine, and fludarabine. BCR-ABL tyrosine kinase inhibitors (TKIs) imatinib and dasatinib inhibit fludarabine and cytarabine uptake. We assessed interactions of bosutinib, dasatinib...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Damaraju, Vijaya L., Weber, Dwayne, Kuzma, Michelle, Cass, Carol E., Sawyer, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009255/
https://ncbi.nlm.nih.gov/pubmed/27432881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.741074
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