IL-28B Genetic Variants Determine the Extent of Monocyte-Induced Activation of NK Cells in Hepatitis C

BACKGROUND: Immuno-genetic studies suggest a functional link between NK cells and λ-IFNs. We recently showed that NK cells are negative for the IFN-λ receptor IFN-λR1 and do not respond to IFN-λ, suggesting a rather indirect association between IL-28B genotype and NK cell activity. METHODS: A total...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Krämer, Benjamin, Finnemann, Claudia, Sastre, Beatriz, Lutz, Philipp, Glässner, Andreas, Wolter, Franziska, Goeser, Felix, Kokordelis, Pavlos, Kaczmarek, Dominik, Nischalke, Hans-Dieter, Strassburg, Christian P., Spengler, Ulrich, Nattermann, Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008784/
https://ncbi.nlm.nih.gov/pubmed/27583440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162068
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