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A Regulated Double-Negative Feedback Decodes the Temporal Gradient of Input Stimulation in a Cell Signaling Network

Revealing the hidden mechanism of how cells sense and react to environmental signals has been a central question in cell biology. We focused on the rate of increase of stimulation, or temporal gradient, known to cause different responses of cells. We have investigated all possible three-node enzymat...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Park, Sang-Min, Shin, Sung-Young, Cho, Kwang-Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008701/
https://ncbi.nlm.nih.gov/pubmed/27584002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162153
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