Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer

Mutant-selective, 3rd-generation EGFR-TKIs were recently developed to control lung cancer cells harboring T790M-mediated resistance. However, the development of resistance to these novel drugs seems inevitable. Thus, we investigated the mechanism of acquired resistance to the mutant-selective EGFR-T...

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Udgivet i:Oncotarget
Main Authors: Park, Ji Hyun, Choi, Yun Jung, Kim, Seon Ye, Lee, Jung-Eun, Sung, Ki Jung, Park, Sojung, Kim, Woo Sung, Song, Joon Seon, Choi, Chang-Min, Sung, Young Hoon, Rho, Jin Kyung, Lee, Jae Cheol
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008340/
https://ncbi.nlm.nih.gov/pubmed/26980747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8013
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