Metformin inhibits 17β-estradiol-induced epithelial-to-mesenchymal transition via βKlotho-related ERK1/2 signaling and AMPKα signaling in endometrial adenocarcinoma cells

The potential role of metformin in treating endometrial cancer remains to be explored. The current study investigated the role of metformin in 17β-estradiol-induced epithelial-mesenchymal transition (EMT) in endometrial adenocarcinoma cells. We found that 17β-estradiol promoted proliferation and mig...

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Udgivet i:Oncotarget
Main Authors: Liu, Zhao, Qi, Shasha, Zhao, Xingbo, Li, Mingjiang, Ding, Sentai, Lu, Jiaju, Zhang, Hui
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008287/
https://ncbi.nlm.nih.gov/pubmed/26824324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7040
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