Clinical impact of ABL1 kinase domain mutations and IKZF1 deletion in adults under age 60 with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL): molecular analysis of CALGB (Alliance) 10001 and 9665

Recent studies have identified oncogenic lesions in Ph+ ALL and ABL1 kinase mutations that confer resistance to tyrosine kinase inhibitors. We sought to determine the prevalence and clinical impact of these lesions in patients on CALGB 10001, a previously reported phase II study of imatinib, chemoth...

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Publicado en:Leuk Lymphoma
Main Authors: DeBoer, Rebecca, Koval, Gregory, Mulkey, Flora, Wetzler, Meir, Devine, Steven, Marcucci, Guido, Stone, Richard M., Larson, Richard A., Bloomfield, Clara D., Geyer, Susan, Mullighan, Charles G., Stock, Wendy
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008253/
https://ncbi.nlm.nih.gov/pubmed/26892479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2016.1144881
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