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How MCM loading and spreading specify eukaryotic DNA replication initiation sites

DNA replication origins strikingly differ between eukaryotic species and cell types. Origins are localized and can be highly efficient in budding yeast, are randomly located in early fly and frog embryos, which do not transcribe their genomes, and are clustered in broad (10-100 kb) non-transcribed z...

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Pubblicato in:F1000Res
Autore principale: Hyrien, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: F1000Research 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007759/
https://ncbi.nlm.nih.gov/pubmed/27635237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.9008.1
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