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Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β
Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1. We recently found that CLC-1 degradation is mediated by cullin 4 ubiquitin ligase complex. It is curren...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5007535/ https://ncbi.nlm.nih.gov/pubmed/27580824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32444 |
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