Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models

Podocyte injury and the appearance of proteinuria are features of minimal-change disease (MCD). Cyclosporin A (CsA) and tacrolimus (FK506) has been reported to reduce proteinuria in patients with nephrotic syndrome, but mechanisms remain unknown. We, therefore, investigated the protective mechanisms...

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Publicat a:Sci Rep
Autors principals: Shen, Xiujin, Jiang, Hong, Ying, Meike, Xie, Zhoutao, Li, Xiayu, Wang, Haibing, Zhao, Jie, Lin, Chuan, Wang, Yucheng, Feng, Shi, Shen, Jia, Weng, Chunhua, Lin, Weiqiang, Wang, Huiping, Zhou, Qin, Bi, Yan, Li, Meng, Wang, Lingyan, Zhu, Tongyu, Huang, Xiaoru, Lan, Hui-Yao, Zhou, Jing, Chen, Jianghua
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007516/
https://ncbi.nlm.nih.gov/pubmed/27580845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32087
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