Protein stitchery: design of a protein for selective binding to a specific DNA sequence.
We present a general strategy for designing proteins to recognize DNA sequences and illustrate this with an example based on the "Y-shaped scissors grip" model for leucine-zipper gene-regulatory proteins. The designed protein is formed from two copies, in tandem, of the basic (DNA binding) region of...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50071/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1409607/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.19.9094 |
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