BRAF V600E mutation correlates with suppressive tumor immune microenvironment and reduced disease-free survival in Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a neoplasm of myeloid origin characterized by a clonal proliferation of CD1a(+)/CD207(+) dendritic cells. Recurrent BRAF V600E mutation has been reported in LCH. In the present report, we confirm the feasibility of the high-specificity monoclonal antibody VE1 f...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Zeng, Kaixuan, Wang, Zhe, Ohshima, Koichi, Liu, Yixiong, Zhang, Weichen, Wang, Lu, Fan, Linni, Li, Mingyang, Li, Xia, Wang, Yingmei, Yu, Zhou, Yan, Qingguo, Guo, Shuangping, Wei, Jie, Guo, Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006923/
https://ncbi.nlm.nih.gov/pubmed/27622040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1185582
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