Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury

Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown. Here we identify two enzymes that regulate the balance o...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Zhao, Jing, Wei, Jianxin, Dong, Su, Bowser, Rachel K., Zhang, Lina, Jacko, Anastasia M., Zhao, Yutong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006730/
https://ncbi.nlm.nih.gov/pubmed/27448760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.07.020
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