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Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinase
Insulin biosynthesis is an essential β-cell function and inappropriate insulin secretion and biosynthesis contribute to the pathogenesis of diabetes mellitus type 2. Previous studies showed that the dual leucine zipper kinase (DLK) induces β-cell apoptosis. Since β-cell dysfunction precedes β-cell l...
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| Publicado no: | Cell Signal |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5006626/ https://ncbi.nlm.nih.gov/pubmed/24726898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2014.04.006 |
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