MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs

Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC-driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim). Transcription factors (EBNAs) encoded by the lymphoma-associated Epstein-Barr virus (EBV) activate MYC and silence BCL2L11. We show t...

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Bibliographic Details
Published in:eLife
Main Authors: Wood, C David, Veenstra, Hildegonda, Khasnis, Sarika, Gunnell, Andrea, Webb, Helen M, Shannon-Lowe, Claire, Andrews, Simon, Osborne, Cameron S, West, Michelle J
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2016
Subjects:
Cancer Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5005034/
https://ncbi.nlm.nih.gov/pubmed/27490482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18270
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