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Identifying protein aggregation mechanisms and quantifying aggregation rates from combined monomer depletion and continuous scattering

Parallel temperature initial rates (PTIR) from chromatographic separation of aggregating protein solutions are combined with continuous simultaneous multiple sample light scattering (SMSLS) to make quantitative deductions about protein aggregation kinetics and mechanisms. PTIR determines the rates a...

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Detalhes bibliográficos
Publicado no:Anal Biochem
Main Authors: Barnett, Gregory V., Drenski, Michael, Razinkov, Vladimir, Reed, Wayne F., Roberts, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004974/
https://ncbi.nlm.nih.gov/pubmed/27510552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2016.08.002
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