15d-PGJ(2)-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation

15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)), a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has physiological properties including pronounced anti-inflammatory activity, though it binds strongly to serum albumin. The use of solid lipid nanoparticles (SLN) can improve therapeu...

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Veröffentlicht in:PLoS One
Hauptverfasser: de Melo, Nathalie Ferreira Silva, de Macedo, Cristina Gomes, Bonfante, Ricardo, Abdalla, Henrique Ballassini, da Silva, Camila Morais Gonçalves, Pasquoto, Tatiane, de Lima, Renata, Fraceto, Leonardo Fernandes, Clemente-Napimoga, Juliana Trindade, Napimoga, Marcelo Henrique
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004889/
https://ncbi.nlm.nih.gov/pubmed/27575486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161796
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