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An Essential Viral Transcription Activator Modulates Chromatin Dynamics

Although ICP4 is the only essential transcription activator of herpes simplex virus 1 (HSV-1), its mechanisms of action are still only partially understood. We and others propose a model in which HSV-1 genomes are chromatinized as a cellular defense to inhibit HSV-1 transcription. To counteract sile...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Gibeault, Rebecca L., Conn, Kristen L., Bildersheim, Michael D., Schang, Luis M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004865/
https://ncbi.nlm.nih.gov/pubmed/27575707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005842
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