IgA1 Protease Treatment Reverses Mesangial Deposits and Hematuria in a Model of IgA Nephropathy

IgA nephropathy (IgAN), characterized by mesangial IgA1 deposits, is a leading cause of renal failure worldwide. IgAN pathogenesis involves circulating hypogalactosylated IgA1 complexed with soluble IgA Fc receptor I (sCD89) and/or anti–hypogalactosylated-IgA1 autoantibodies, but no specific treatme...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Lechner, Sebastian M., Abbad, Lilia, Boedec, Erwan, Papista, Christina, Le Stang, Marie-Bénédicte, Moal, Christelle, Maillard, Julien, Jamin, Agnès, Bex-Coudrat, Julie, Wang, Yong, Li, Aiqun, Martini, Paolo G.V., Monteiro, Renato C., Berthelot, Laureline
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2016
Subjects:
Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004657/
https://ncbi.nlm.nih.gov/pubmed/26850635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015080856
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