Ultra-deep sequencing leads to earlier and more sensitive detection of the tyrosine kinase inhibitor resistance mutation T315I in chronic myeloid leukemia

Chronic myeloid leukemia cells acquire resistance to tyrosine kinase inhibitors through mutations in the ABL1 kinase domain. The T315I mutation mediates resistance to imatinib, dasatinib, nilotinib and bosutinib, whereas sensitivity to ponatinib remains. Mutation detection by conventional Sanger seq...

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Publicado no:Haematologica
Main Authors: Baer, Constance, Kern, Wolfgang, Koch, Sarah, Nadarajah, Niroshan, Schindela, Sonja, Meggendorfer, Manja, Haferlach, Claudia, Haferlach, Torsten
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004462/
https://ncbi.nlm.nih.gov/pubmed/27102501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.145888
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