Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are required to target Ataxia Telangiectasia Mutated-deficient chron...

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Publicado no:Haematologica
Main Authors: Agathanggelou, Angelo, Weston, Victoria J., Perry, Tracey, Davies, Nicholas J., Skowronska, Anna, Payne, Daniel T., Fossey, John S., Oldreive, Ceri E., Wei, Wenbin, Pratt, Guy, Parry, Helen, Oscier, David, Coles, Steve J., Hole, Paul S., Darley, Richard L., McMahon, Michael, Hayes, John D., Moss, Paul, Stewart, Grant S., Taylor, A. Malcolm R., Stankovic, Tatjana
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004424/
https://ncbi.nlm.nih.gov/pubmed/25840602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.115170
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