Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1

The matrix protein 1 (M1) of influenza A virus (IAV) exists as a three-dimensional oligomeric structure in mature virions with high sequence conservation across different IAV subtypes, which makes it a potential broad spectrum antiviral target. We hypothesized that impairing self-association of M1 t...

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Pubblicato in:Sci Rep
Autori principali: Mosier, Philip D., Chiang, Meng-Jung, Lin, Zhengshi, Gao, Yamei, Althufairi, Bashayer, Zhou, Qibing, Musayev, Faik, Safo, Martin K., Xie, Hang, Desai, Umesh R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004101/
https://ncbi.nlm.nih.gov/pubmed/27573445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32340
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