Synthesis and Antitumor Activity of Selenium-Containing Quinone-based Triazoles Possessing Two Redox Centres, and their Mechanistic Insights

Selenium-containing quinone-based 1,2,3-triazoles were synthesized using click chemistry, the copper catalyzed azide-alkyne 1,3-dipolar cycloaddition, and evaluated against six types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), PC3 (human p...

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Udgivet i:Eur J Med Chem
Main Authors: da Cruz, Eduardo H. G., Silvers, Molly A., Jardim, Guilherme A. M., Resende, Jarbas M., Cavalcanti, Bruno C., Bomfim, Igor S., Pessoa, Claudia, de Simone, Carlos A., Botteselle, Giancarlo V., Braga, Antonio L., Nair, Divya K., Namboothiri, Irishi N. N., Boothman, David A., Júnior, Eufrânio N. da Silva
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003678/
https://ncbi.nlm.nih.gov/pubmed/27341379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.06.019
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