Macrophage Notch ligand Delta-like 4 promotes vein graft lesion development: implications for the treatment of vein graft failure

OBJECTIVE: Despite its large clinical impact, the underlying mechanisms for vein graft failure remain obscure and no effective therapeutic solutions are available. We tested the hypothesis that Notch signaling promotes vein graft disease. APPROACH AND RESULTS: We used two biotherapeutics for Delta-l...

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Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Koga, Jun-ichiro, Nakano, Toshiaki, Dahlman, James E., Figueiredo, Jose-Luiz, Zhang, Hengmin, Decano, Julius, Khan, Omar F, Niida, Tomiharu, Iwata, Hiroshi, Aster, Jon C., Yagita, Hideo, Anderson, Daniel G., Ozaki, C. Keith, Aikawa, Masanori
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003117/
https://ncbi.nlm.nih.gov/pubmed/26404485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.305516
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