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Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.

The physiologic balance between the two regulatory subunit isoforms, RI and RII, of cAMP-dependent protein kinase is disrupted in cancer cells; growth arrest and differentiation of malignant cells can be achieved when the normal ratio of these intracellular signal transducers of cAMP is restored by...

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Détails bibliographiques
Auteurs principaux: Pinto, A, Aldinucci, D, Gattei, V, Zagonel, V, Tortora, G, Budillon, A, Cho-Chung, Y S
Format: Artigo
Langue:Inglês
Publié: 1992
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC50028/
https://ncbi.nlm.nih.gov/pubmed/1329084
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