Early life adversity in piglets induces long-term upregulation of the enteric cholinergic nervous system and heightened, sex-specific secretomotor neuron responses

BACKGROUND: Early life adversity (ELA) is a risk factor for the later-life onset of gastrointestinal (GI) diseases such as irritable bowel syndrome (IBS); however, the mechanisms are poorly understood. Here, we utilized a porcine model of ELA, early weaning stress (EWS), to investigate the influence...

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Pubblicato in:Neurogastroenterol Motil
Autori principali: Medland, Julia E., Pohl, Calvin S., Edwards, Laura L., Frandsen, Shellsea, Bagley, Kristen, Li, Yihang, Moeser, Adam J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002263/
https://ncbi.nlm.nih.gov/pubmed/27134125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nmo.12828
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