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Recognition of Poly-Ubiquitins by the Proteasome through Protein Re-folding Guided by Electrostatic and Hydrophobic Interactions
Specificity of protein degradation by cellular proteasomes comes from tetra-ubiquitin recognition. We carry out molecular dynamics simulations to characterize how the ubiquitin receptor Rpn10 recognizes in the 26S proteasome K(48)-linked tetra-ubiquitin. In the binding pose, ubiquitin and Rpn10 inte...
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| 發表在: | J Phys Chem B |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5001906/ https://ncbi.nlm.nih.gov/pubmed/27012670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b01327 |
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